Sunday, March 13, 2011

A New Treatment For Atrial Fibrillation in the Elderly?: The (IR)relevance of Clincial Resarch to Geriatric Populations


Atrial Fibrillation is a very common heart rhythm that substantially increases the risk for stroke. The likelihood of having atrial fibrillation increases markedly with age. In Geriatrics practice, where many of our patients are in their 80's and 90's, we see patients with atrial fibrillation all the time.

The good news is that there is a treatment that has been available for many years that dramatically reduces the risk of stroke in patients with atrial fibrillation. Warfarin, an anticoagulant or blood thinner, is very effective at stroke reduction. However, warfarin can be hard to use. If too much is given, the risk of bleeding complications becomes high. If too little is given, it becomes ineffective at preventing stroke. Some studies have suggested that when warfarin is properaly dosed, almost all of the excess stroke risk of atrial fibrillation goes away with only a modestly increased risk of bleeding. Unfortunately, in many patients, it is hard to continuously properaly dose warfarin.

Because of concerns about the risk for bleeding, and difficulties with the required monitoring, many patients with atrial fibrillation are not treated with warfarin. The oldest patients are less likely to be treated with warfarin as problems such as frailty and falls increase concerns about bleeding and adherance to the required monitoring becomes more difficult.

While these concerns are legitimate, in clinical practice they may be used too often as reasons for withholding warfarin. While higher age increases the risk of warfarin complications, higher age also increases the risk of stroke, and the risk of stroke increases at a greater rate than the risk of bleeding complications.

Many of the oldest old are treated with aspirin instread of warfarin. Aspirin does somewhat reduce stroke risk, but not nearly as much as warfarin. Old age alone should never be viewed as a contraindication for warfarin. Many patients in their 90's are safely managed with warfarin.

None the less, there is a need for better treatments for patients who can not tolerate warfarin. A recent article in the New England Journal of Medicine provides impressive evidence that a new agent, Apixiban, may be that treatment.

This study enrolled 5599 persons with atrial fibrillation in whom it was felt warfarin was unsuitable. The most common reason was a belief that the patient could not comply with the monitoring. Patients were randomized to either aspirin or apixaban. The study was stopped early because apixaban was much more effective. In particular:

  • Patients on Apixaban had a much lower risk of stroke or embolism than those on Aspirin (1.6% versus 3.7% per year).
  • The rate of death was somewhat lower with apixaban (3.5% vs. 4.4% per year), though this was not quite statistically significant
  • Rates of major bleeding were not higher with Apixaban compared to aspirin (1.4% vs. 1.2% per year)
The study provides strong evidence that Apixaban provides substantial benefit in terms of stroke reduction over aspirin with a reasonable safety profile. It seems likely most patients who can not tolerate Warfarin will be good candidates for Apixaban as a superior alternative to aspirin. An important caution though: Warfarin is still the treatment of choice---Apixaban should only be used in patients who absolutely can not tolerate warfarin.

So, this study does seem like a big advance. But there is one big problem, a problem pervasive in clinical research. The clinical question in this study--revolving around alternatives in patients with atrial fibrillation who can not tolerate warfarin is overwhelmingly a problem of the oldest old. The patients for whom Apixaban would be most useful include
  • The very old: Patients in their 80's and 90's
  • The very frail: Patients with mobility limitations, a history of repeated falls, and dependence in their basic activities of daily living
  • Elders with cognitive difficulties
  • Elders in long term care settings such as nursing homes
Despite many excellent features of this study, it fell unacceptably short in terms of selecting a patient population that helps us understand the role of Apixabab in the very patients who are the most likely candidates for this therapy.

The average age of enrollment of 70 is unacceptably low---and far lower than the age of a patient who is a typical candidate for this therapy. It appears there were very few patients in their 90's, even though atrial fibrillation is exceptionally common in this age range and their is an urgent need for warfarin alternatives in this population. It is not clear if any of the patients were in long term care.

Further, the study fails to report on essential clinical meaures such as need for assistance with basic and instrumental activities of daily living, falls history, cognitive function, or social support. Describing a study of a Geriatric problem without these measures is like conducting a study of heart failure and not measuring ejection fraction. Not only are these essential measures for describing the subjects and understanding generalizability, but they were essential candidates for subgroup analysis as they could have influenced the effectiveness of treatment

While the investigators have made an important contribution, it is unfortunate that for what is essentially a Geriatric problem, the study was not designed in such a way to make it most relevent to the Geriatric population.

Unfortunately, this problem is the norm in clinical research. And arguably, by at least hitting a mean age of 70, the investigators have performed above the norm. However, the norm is completely unacceptable.
It is time the public, advocates for older persons, the NIH, and the FDA start to demand better.

by: Ken Covinsky

4 comments:

SB. Leavitt, MA, PhD said...

If my calculations are correct, the NNT for stroke/embolism with Apibaxan would be 50, for death the NNT=111. I don't know of the costs of this new drug, or the potential adverse reactions, but I'm wondering if this would be an appropriate alternative to ASA for the oldest of the old? -- SBL

Christopher Langston said...

Thanks for this analysis Ken. Given the lead time for designing studies and recruiting participants, it will be a few years before we can even hope for change in recruiting those for whom the clinical research questions are most relevant. In addition to leaning on NIH and FDA, I suspect we should also lobby IRB organizations. I think frail older adults are often excluded because of real or imagined IRB barriers. The practical reality that older persons are already subject to these problems and using many medicines without evidence seems to get ignored. My favorite IRB comment continues to be "I'm not sure it is ethical to randomize people to usual care."

ken covinsky said...

Thanks Dr. Leavitt and Langston for your comments.

At least based on this study, when warfarin can not be tolerated, Apibixan seems like a good alternative to aspirin. However, it is quite a shame the study seriously underrepresented the oldest old, who are the patients most in need of an alternative to warfarn. Will still make it hard to know what to do in this population

Chris---I had not thought of the IRB angle, but I agree it could be a big part of the problem. It would be interesting to learn how often IRBs discourage enrollment of the frail---perhaps because of consent issues, or concerns that they are "too frail." Perhaps they need to focus on the ethics of not learning what are the best treatments in these patients.

Jaerou Kim said...

Thank you for your valuable post. We have decided to share it with our global physician audience at PhysicianNexus.com: http://physiciannexus.com/forum/topics/a-new-treatment-for-atrial

Jaerou Kim
Team Member
www.PhysicianNexus.com
Physicians Comparing Treatments Worldwide