Skip to main content

Parenteral Fluids at the End of Life

It is better to die dry than wet. At least that is the gist of traditional thinking in hospice and palliative care, where parenteral (IV or subcutaneous) fluids are often avoided at the very end of life to prevent fluid buildup in the lungs and other organs.

The problem is that delirium often complicates end of life care as well. It is one of the four most common emergency calls for individuals receiving palliative care in the home and a common reason for admissions into inpatient hospice units. Reduced oral intake, a part of the natural dying process, may result in dehydration in some but not all individuals at the end of life, and may be a factor in the development delirium. Studies in the geriatric literature suggest that early recognition of dehydration and volume repletion is an important component of delirium prevention.

So, how do we reconcile our desire to avoid the unintended consequences of IV hydration in those at the end of life with that of treating dehydration to prevent delirium?  Some argue for a greater use of parenteral fluids in these patients to improve quality of life, at the very least for those with some evidence of dehydration.  However, the question remains, does IV hydration improve quality of life and decrease incidence of delirium, or will it just worsen symptoms at the end of life?

Dr. Eduardo Bruera and colleagues from MD Anderson add some evidence to how best to manage fluids at the end of life thanks to a study recently published in the Journal of Clinical Oncology. The authors randomized 129 individuals with advanced cancer from 6 hospices to either parenteral subcutaneous hydration of 1 L per day of normal saline or placebo.  In order to maintain blinding for both patients and staff, the placebo was a 100ml a day of saline injected over a similar 4 hour period per day as the fluids in the intervention group.

Inclusion criteria included advanced cancer, reduced oral intake of fluids with evidence of mild or moderate dehydration, at least mild symptoms of fatigue, hallucinations, sedation, and myoclonus, a life expectancy of less than 1 week, , and a Memorial Delirium Assessment Scale (MDAS) score less than 13 (i.e not severe delirium). Those with severe dehydration were excluded as were individuals with renal failure, congestive heart failure, or a history or clinical evidence of bleeding disorders.

The primary outcome was change from baseline to day 4 for the sum of four dehydration symptoms (fatigue, myoclonus, sedation and hallucinations). They also included a rather complete amount of secondary outcomes including:

  • Individual items on a symptom assessment scale - the Edmonton Symptom Assessment Scale (ESAS)
  • Two dementia scales – the Memorial Delirium Assessment Scale (MDAS) and Nursing Delirium Screening Scale (NuDESC) – and one agitation scale
  • A quality of life scale – the Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT-F)
  • Dehydration assessment scale (the Dehydration Assessment Scale)
  • Labs including creatinine, urea, and electolytes
  • Overall survival.

In the intention-to-treat analysis, there were no statistically significant differences between the IV hydration group and the placebo group at either 4 days or 7 days in regards to:
  • The sum of the four dehydration symptoms (-3.3 vs -2.8, P=0.77)
  • Individual symptom evaluation based on the ESAS
  • Overall delirium scores based on the MDAS
  • Quality of life scores
  • Dehydration assessment scores
  • Median survival

The authors did find some differences in some measures such as night-time delirium scores, which was worse in the placebo group. However, given the numerous secondary outcomes (47 of them), I wouldn't place much weight on this, as by pure chance at least two of these outcomes will be positive using a P of 0.05.

One big limitation of the study was that it was underpowered. The planned sample size was 150 patients, but funding issues required termination of the study after 129 patients. This was likely due to the strict inclusion and exclusion criteria. So, you can argue that the authors didn't find a difference because they didn't enroll enough patients (a Type II error). This may be a classic Type II error where no significant difference between groups are reported when in fact such a difference exists.  I would be surprised though if the authors enrolled another 21 patients that a clinically significant result would have materialized for the primary outcome since it didn't look like a trend was developing (-3.3 vs -2.8, P=0.77).

So in the end, we have some data to suggest that IV hydration of 1 liter is unlikely to provide a meaningful benefit to most hospice patients with advanced cancer with mild to moderate dehydration (but not severe).

by: Eric Widera (@ewidera)


Moshe said…
I have not yet had a chance to read the entire study, so forgive me if this is addressed there.

Why was only one liter of fluid given? Is it possible that the reason no difference was found is because both groups were dehydrated, and the degree of dehydration did not show a difference clinically?
Eric Widera said…
Great question. The study gave 1 Liter of fluids per day "until the patient was unresponsive, developed progressive coma, or died."

Per the authors "a volume of 1,000 mL per day was chosen on the basis of previous studies demonstrating that this amount was adequate to improve clinical outcomes in palliative care patients."

This still may not have been enough to completely reverse mild to moderate dehydration though.
Anonymous said…
I have come to believe that at the end of life the ethical dilemma is to "do no harm." when we know that there is nothing more that we can do medically for the patient. Isn't that what is imparted to the patient and family. Thus, it is more important than the one liter of fluid that is given to the patient. It is the number of IV initiations and sticks that cause pain, the number of times the patient has to be suctioned, or the breaks in the skin caused by incontinence of bowel or bladder. So why we debate IV hydration at the end of life it may need to be shrouded by "do no harm".

Popular posts from this blog

Practical Advice for the End of Life: A Podcast with BJ Miller

This week we talk with BJ Miller, hospice and palliative care physician, public speaker, and now author with Shoshana Berger of the book "A Beginner's Guide to the End."

As we note on the podcast, BJ is about as close as we get to a celebrity in Hospice and Palliative Care.  His TED Talk "What Really Matters at the End of Life" has been viewed more than 9 million times.  As we discuss on the Podcast, this has changed BJ's life, and he spends most of his working time engaged in public speaking, being the public "face" of the hospice and palliative care movement.

The book he and Berger wrote is filled to the brim with practical advice.  I mean, nuts and bolts practical advice.  Things like:
How to clean out not only your emotional house but your physical house (turns out there are services for that!)Posting about your illness on social media (should you post to Facebook)What is the difference between a funeral home and mortuaryCan I afford to die?  …

Caring, and the Family Caregivers We Don’t See

Over lunch at a restaurant in Manhattan, my father and I talked about long-term care insurance and the emergence of senior centers and nursing homes across the U.S. that offer a variety of ethnic cuisines and cultural events, catering not only to a growing population of adults over 65, but also, to an increasingly diverse population of adults who call the U.S. their home. This conversation was different from many similar ones before it – we weren’t talking about my research; we were talking about our own lives.
My parents immigrated to the U.S. in the late ‘70s and early ‘80s, following their parents’ advice on professional opportunities that seemed unimaginable in India at the time. Although they considered moving back soon after to care for their aging parents and to raise children, they ultimately decided to stay in the U.S. As I chronicled earlier, my paternal grandparents lived with us until I completed middle school, at which point they returned to India and lived with my mater…

Top 25 Studies in Hospice and Palliative Care (#HPMtop25)

by: Kara Bishoff (@kara_bischoff )

Back in 2015 we wrote a post asking for input on what articles should belong on a list of the top 25 articles in hospice and palliative care.   We decided to focus on hospice palliative care studies and trials - as opposed to review articles, consensus statements and opinion pieces.

Here’s what we came up with. It was hard to pick just 25! We highly prioritized clinical utility and tried to achieve diversity & balance. Many others are worthy of inclusion. Take a look and let us know if you have suggested changes for next year.

Module 1: Symptom Management
Randomized, Double-Blind, Placebo-Controlled Trial of Oral Docusate in the Management of Constipation in Hospice Patients. Tarumi Y et al. JPSM, 2013.Once-Daily Opioids for Chronic Dyspnea: A Dose Increment and Pharmacovigilance Study. Currow DC et al. JPSM, 2011.Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomise…