Skip to main content

Is antiepileptic therapy indicated for primary prevention after an ischemic stroke?

Mrs. C is a 79 year old nursing home resident woman who suffered an ischemic stroke about 10 months ago. She also suffers from depression, multiple frequent falls, dementia with behavioral disturbances, and psychosis. She was started on Levetiracetam (Keppra) 750 mg by mouth twice a day for seizure prophylaxis in the hospital after her stroke. The consulting neurologist at the nursing home recommended continuation of this antiepileptic for seizure prophylaxis. Thinking about how can I optimize her care, I wondered if in older adult patients with history of an ischemic cerebrovascular event, are antiepileptic drugs indicated for seizure prophylaxis?

To find the answer to this Therapy question, I began my search with Pubmed Clinical Queries using the terms “older adults with stroke and antiepileptic drugs for seizure prophylaxis” looking for randomized controlled trials or meta-analyses. The result of my search resulted in a Cochrane review originally published in 2010 with an update in 2014, which included articles evaluating the effects of antiepileptics for primary and secondary prevention.

Photo by: Emilio Garcia
The most recent Cochrane review from 2014 found only one trial, a randomized controlled double blinded trial, comparing valproic acid with placebo for primary prevention of seizures in 72 adults (over 18 years of age) with an average age of 68.5 years with spontaneous non-aneurysmal, non-traumatic intracerebral hemorrhage. The dose of valproic acid used in this study was 800 mg/d (400 mg twice daily, entirely oral). The primary outcome was seizure occurrence at 1 year, based on nursing or family / caregiver report or a witnessed episode.

Seven out of 36 in the valproic acid group and 8 out of 36 in the placebo group had a seizure after 12 months follow up. These results translate to a calculated relative risk ratio of 0.86 (see table). No confidence interval was reported, but it was stated that there was no statistically significant difference between the 2 groups. Regarding adverse events, there was no increase in sedation, rate of intubation or length of hospitalization in the intervention group compared to the control group. Two participants in the intervention group experienced a mild liver dysfunction that did not warrant treatment discontinuation.



Seizure
No Seizure


Valproic acid
7
29
Risk of seizure in intervention group = 
7 / 7+29 = 0.19
Placebo
8
28
Risk of seizure in control group = 
8 / 8+28 = 0.22
Relative Risk Ratio = 0.19 / 0.22 = 0.86

This RCT was well designed and with low risk of bias (randomization, blinding, etc); nevertheless there is a possibility of a type 2 error (false negative) when a negative study is reviewed, especially one with a small sample size. We could not find details of study power calculation done by the authors to ensure a sample size large enough to detect a difference between the groups if one exists. This is particularly important to know because some of the secondary outcomes showed a trend towards a benefit from valproic acid.

In summary, the use of antiepileptic drugs after hemorrhagic stroke is of questionable value. Interestingly, there is no study that evaluates the use of antiepileptic medications in ischemic stroke (the more common form of stroke). The American Association of Neurological Surgeons and Congress of Neurological Surgeons in June 2014, in view of the lack of available evidence, recommended against the routine use seizure prophylaxis in patients following ischemic stroke, as part of their Choosing Wisely® campaign.

Back to Mrs. C
After discussing this case and without strong evidence supporting the routine use of antiepeliptic drugs for prophylaxis, we slowly started titrated off the antiepileptic drug over a period of 4 months and Mrs. C has not experienced any complications. The need for chronic antiepileptic use should be evaluated periodically in stroke patients and aspects such as side effects, risk of falls, polypharmacy, prognosis and cost effectiveness, should be taken into consideration.

By: Vanessa Rodriguez, MD, Geriatrics and Palliative Medicine fellow at Icahn School of Medicine at Mount Sinai, New York.

This post is part of the #GeriCases series, in which we discuss a clinical case in geriatrics and palliative medicine and the attempt to provide patient-centered care with the use of best available evidence.
Ravishankar Ramaswamy, MD
@RavRamaswamy
Section Editor, #GeriCases

Comments

Mike Steinman said…
Bravo on your brief and thoughtful discussion of the topic!
Harshil Patel said…
Amazing! Thanks a lot for sharing the good humor. US Open Live Streaming You can also check the live scores by checking this US Open Live Scores and US Open Live Scores . To make the most of the US open Final check out US Open Mens final and US Open womens final and US Open final 2015 . This is all about the overal view and you can also check the
US Open Mens Final and
US Open Womens Final
and US Open final 2015 so make sure that you don't miss a single match from today to explore the best of US open Tennis 2015!
Anonymous said…
Great article. thank you so much for the share

Buy cheap essay online
Anonymous said…
Great article. thank you so much for the share

Buy cheap essay online
One example of such a recovery option is mirror therapy. Much research remains to be done to fully prove efficacy of mirror therapy. But for some stroke survivors mirror therapy appears to be a promising and effective option for reestablishing cortical control over wayward limbs stroke rehabilitation program

Popular posts from this blog

Practical Advice for the End of Life: A Podcast with BJ Miller

This week we talk with BJ Miller, hospice and palliative care physician, public speaker, and now author with Shoshana Berger of the book "A Beginner's Guide to the End."

As we note on the podcast, BJ is about as close as we get to a celebrity in Hospice and Palliative Care.  His TED Talk "What Really Matters at the End of Life" has been viewed more than 9 million times.  As we discuss on the Podcast, this has changed BJ's life, and he spends most of his working time engaged in public speaking, being the public "face" of the hospice and palliative care movement.

The book he and Berger wrote is filled to the brim with practical advice.  I mean, nuts and bolts practical advice.  Things like:
How to clean out not only your emotional house but your physical house (turns out there are services for that!)Posting about your illness on social media (should you post to Facebook)What is the difference between a funeral home and mortuaryCan I afford to die?  …

Improving Advance Care Planning for Latinos with Cancer: A Podcast with Fischer and Fink

In this week's GeriPal podcast we talk with Stacy Fischer, MD and Regina Fink, RN, PhD, both from the University of Colorado, about a lay health navigator intervention to improve advance care planning with Latinos with advanced cancer.  The issue of lay health navigators raises several issues that we discuss, including:
What is a lay health navigator?What do they do?  How are they trained?What do lay health navigators offer that specialized palliative care doesn't?  Are they replacing us?What makes the health navigator intervention particularly appropriate for Latinos and rural individuals?  For advance care planning? Eric and I had fun singing in French (yes French, not Spanish, listen to the podcast to learn why).
Enjoy! -@AlexSmithMD




You can also find us onYoutube!



Listen to GeriPal Podcasts on:
iTunes Google Play MusicSoundcloudStitcher

Transcript

Eric: Welcome to the GeriPal podcast. This is Eric Widera.

Alex: This is Alex Smith.

Eric: And Alex, I'm really excited about toda…

The Dangers of Fleet Enemas

The dangers of oral sodium phosphate preparations are fairly well known in the medical community. In 2006 the FDA issued it’s first warning that patients taking oral sodium phosphate preparations are at risk for potential for acute kidney injury. Two years later, over-the-counter preparations of these drugs were voluntarily withdrawn by the manufacturers.  Those agents still available by prescription were given black box warnings mainly due to acute phosphate nephropathy that can result in renal failure, especially in older adults. Despite all this talk of oral preparations, little was mentioned about a sodium phosphate preparation that is still available over-the-counter – the Fleet enema.

Why Oral Sodium Phosphate Preparations Are Dangerous 

Before we go into the risks of Fleet enemas, lets spend just a couple sentences on why oral sodium phosphate preparations carry significant risks. First, oral sodium phosphate preparations can cause significant fluid shifts within the colon …